And here we have definitive proof that you can do anything with python, from the genii over at xkcd.com. Does anyone else have any evidence to share?
License Info: http://xkcd.com/license.html
Well, tlb wrote the prototype for his Segway-like scooter in Python. (That may be where the xkcd idea cam from.)
Resolver One is an Excel clone that maintains a complete textual Python representation of its spreadsheet. So you can write arbitrary Python code that runs before, during and after the spreadsheet is built to transform your data using a stateful, OOP language instead of the crappy functional language that comes with Excel. Disclaimers: it's .NET (Windows only) and was still in beta last time I played with it. Still, a cool idea.
In theory, since it runs on .NET, it should be easy for the developers to add support for IronRuby, F#, C#, VB, etc. But right now it's IronPython only.